Recombinant cytokines: The original cancer immunotherapy

Reading time: 4 minutes Bekah Schulz Many people are excited about checkpoint inhibitors in cancer immunotherapy. In fact, the 2018 Nobel Prize in medicine was awarded for the development of two checkpoint inhibitors PD-1/L1 (Opdivo/Keytruda) and CTLA-4 (Yervoy). However, cancer immunotherapy is not a new concept. In fact, in 1986, recombinant interferon (IFN) alpha was …

Vaccines as Cancer Prevention and Therapies

Rachel Cherney Cancer is a complex set of diseases, characterized by uncontrolled growth and metastasis, destroying important organs and bodily systems. It can occur in almost any part of the body, and in most cases, it is impossible to determine how or when it will develop, certain genetically linked cancers perhaps being an exception. Because …

Dealing With The Pitfalls of Checkpoint Security

Jason Tetro If you’ve ever traveled internationally, you know you need a passport. This document is your access pass to the world. What you might not know is that this rather plain looking document is filled with a variety of different checkpoints to ensure authenticity. Some passports have biometric chips, others have incorporated images only …

Helping Our Body’s Killers Kill off Cancer, Naturally

Nisitha Sengottuvel At OncoBites, we’ve talked about many facets of cancer, the many internal and external factors that can affect tumor growth, and the established and developing methods to detect and treat cancer. We’ve also begun to cover the many ways in which biomedical science falls short in effectively treating cancer. Being diagnosed with cancer …

Can mental state affect tumor growth? The link between psychology, immunology, and oncology

Shaye Hagler At Oncobites, we’ve been talking a lot about the role of immunity in cancer. Understanding the immune system is vital to understanding both what drives cancer and what protects us against it. One of the biggest paradoxes in cancer research is that immune system activation is important in fighting cancer via a process …

Immune cells work together to enable successful cancer therapy

Morgan McSweeney A group of researchers from the University of California - San Francisco recently found that the presence of a certain group of immune cells in tumors (“stimulatory dendritic cells,” or SDCs) can predict better cancer outcomes, at least in melanoma patients. For example, in patients treated with checkpoint inhibitors (drugs that work by …