Too Much Potassium Might Be Poisoning Your Anti-Tumor Immunity

Reading time: 4 minutes Sara Musetti Cancer immunotherapy has been a very hot topic here at OncoBites (because it’s a hot topic right now among cancer researchers too), but let me be super clear ⎯ it is COMPLICATED. Your immune system is balanced extremely delicately to avoid sending you into shock each time you are …

Overcoming the Limitations of CAR-T Therapy: Burnout

Reading time: 4 minutes Alex S. Woodell Marathon runners are an interesting breed. In order to complete the grueling 26.2 mile circuit, they must push their mental and physical boundaries to the limit. Seasoned runners possess great strength, focus, resilience, and determination. Each of these qualities is a testament to the intense training schedules they …

Sneaking into the non-conventional niches: Using gamma delta T cells to fight cancer

Reading time: 6 minutes Payal Yokota Despite the advent and access to a variety of targeted immunotherapy approaches, the current paradigm for solid tumors still remains if you can cut it out – you do! Depending on the grade of tumor and degree of metastasis, there’s a substantial risk of tumor resurgence.  In those cases, …

Recombinant cytokines: The original cancer immunotherapy

Reading time: 4 minutes Bekah Schulz Many people are excited about checkpoint inhibitors in cancer immunotherapy. In fact, the 2018 Nobel Prize in medicine was awarded for the development of two checkpoint inhibitors PD-1/L1 (Opdivo/Keytruda) and CTLA-4 (Yervoy). However, cancer immunotherapy is not a new concept. In fact, in 1986, recombinant interferon (IFN) alpha was …

Vaccines as Cancer Prevention and Therapies

Rachel Cherney Cancer is a complex set of diseases, characterized by uncontrolled growth and metastasis, destroying important organs and bodily systems. It can occur in almost any part of the body, and in most cases, it is impossible to determine how or when it will develop, certain genetically linked cancers perhaps being an exception. Because …