Profiling the killer: Using gene sequencing to guide management in pancreatic cancer

Manisit Das In earlier OncoBites articles, we discussed how genetic testing is increasingly used to guide cancer management. Cancer arises due to changes in our DNA sequences that make up our genes, which we refer to as gene mutations. By analyzing the genetic signatures within the tumor, clinicians can make better-informed choices to streamline the …

When math meets lab: The power of modeling in cancer biology

Varshit Dusad 'All models are wrong, some are useful!' - George Box The advancement of biological research relies on understanding how the different moving parts interact with each other, forming an integrated system. To better understand a system we often resort to models which help us develop a logical framework of these interactions, offering us …

Cancer Resistance – Insights from the Animal Kingdom

 Rachel Cherney Most of us have been affected by cancer, whether we ourselves or someone we know has been diagnosed. It can be caused by various lifestyle habits, external or environmental factors, and genetics, and it’s extremely prevalent; as of 2015, 1 in 6 deaths worldwide was due to cancer. As described in a previous …

Feeling the ‘heat’ from neighbors: Microenvironment driving cancers in the gut

Manisit Das Not long ago Tamara mentioned in her OncoBites article that it is often hard to determine what factors drive cancer. Even after a mutation responsible for fueling cancer growth is identified, we do not always know how that mutation contributes to tumor formation. Understanding these mechanisms is however quite important. As we gain …