The Ubiquitin System and Why Researchers Are Targeting it for Cancer Therapy

Reading time: 4 minutes Kedar Puvar Cancerous cells by definition are constantly growing and multiplying and therefore have devised ways to sustain that growth. If one wishes to create a brand new therapeutic against cancer, it’s necessary to identify molecular mechanisms that cancer cells use to grow, then attempt to shut down that mechanism with …

The Many Faces of Tumor Scavenging

Reading time: 8 minutes Alex S. Woodell Prologue   The tumor microenvironment (TME) is a desolate place. Nutrients are sparse, and living conditions are hostile for the resident cells. This poorly perfused, alien landscape is filled with leaky, tortuous vessels. The interstitial fluid pressure is high, severely compromising nutrient delivery mechanisms. It’s not a place …

Bacteria in Cancer therapy: Friend or Foe?

Reading time: 5 minutes Varshit Dusad Bacteria are our unallied neighbors, which depending upon circumstances chooses to be our friend or foe. While bacteria such as E.coli have often been the workhorses for molecular biology studies, they have other uses as well. Surprisingly, they have enormous potential for cancer therapy. No, I am not talking …

Players in Cancer Metastasis and Relapse

Reading time: 5 minutes Rachel Cherney Patients with metastatic cancer usually have a lower survival rate than patients without metastatic cancer, so it is important to understand how metastatis occurs, so we can learn how to improve patient survivability. Metastatic cancer makes up about 90% of cancer deaths. Cancer metastasis occurs when tumor cells break …

When good cells go bad: White blood cells may aid in tumor recurrence

Reading time: 4 mins Sara Musetti “I lit up like a Christmas tree, Hazel Grace.” This line, from John Green’s bestselling novel The Fault in Our Stars, hits hard. A young teenage survivor of cancer has had a widespread relapse picked up in one of his many routine scans since going into remission years earlier. …

Hold the sugar: identifying the contributions of high blood glucose to poor cancer outcomes

Tamara Vital We’ve talked at Oncobites about how many factors can cause or contribute to cancer. We’ve discussed how tumors arise from cells that have acquired mutations (could be inherited). Many of these factors have been related to external exposures like UV exposure from the sun or cigarette smoking that cause mutations that contribute to …