Reading time: 4 minutes Chris Wang Unlike the Merriam Webster definition of promiscuous, describing a kinase inhibitor as promiscuous actually refers to the number of kinases it inhibits. The more promiscuous an inhibitor is, the higher number of off-targets it has. Traditional drug development strategies avoid promiscuous compounds because off-target effects can lead to side... Continue Reading →
Reading time: 3 minutes Rachel Cherney Six feet. Two meters. This is the length of DNA we have in each one of our cells. That’s almost the height of Michael Jordan! But those six feet of DNA need to fit into a tiny space that is between 5-10 micrometers. To put it into perspective, that's... Continue Reading →
Reading time: 5 minutes Chris Wang Chemotherapy is a mainstay of cancer treatment, yet many times it is temporarily withheld or stopped due to significant toxicity. This is because chemotherapy drugs cannot differentiate between killing cancer cells and killing fast growing healthy cells, such as cells in your bone marrow. These cells divide quickly because... Continue Reading →
Reading time: 5 minutes Brittany Avin McKelvey Many of us are enticed by the possibility of extending our lives, towards the goal of one day being able to live forever. This wish may be closer to becoming reality with the promise of some research in which the activation of only one enzyme, usually turned off... Continue Reading →
Reading time: 6 minutes Kate Secombe Have you ever thought about how the cells in our body die? There are many ways a cell can die due to both external or internal factors, playing a role in keeping the body healthy and removing dangerous cells from the body system. When cells fail to listen to... Continue Reading →
Reading time: 4 minutes Daniel Zhong Before we believe headlines proclaiming “Cancer is cured”, it is crucial to understand that developing a therapy that universally cures all cancers is highly unrealistic as our knowledge surrounding mechanisms of cancer progression advances. While we do have non-curative treatments for some types of cancer such as chemotherapy and... Continue Reading →
MaryAnn Bowyer Reading Time: 3 minutes When we think of cancer cells, we often imagine a mastermind cell that has somehow managed to evade all of our body’s natural defenses as well as even modern day science. However, years of scientific research and publications have shown that the “mastermind” behind this particular cell is, in... Continue Reading →
Reading time: 3 minutes Michael Marand You may be familiar with the handy ‘Find My iPhone’ feature that comes with Apple cell phones. This feature uses radio waves from cell towers to direct you precisely to the spot where you dropped your device. Following similar principles, physicians can use imaging techniques to obtain signals from... Continue Reading →
Reading time: 5 minutes Keighley Reisenauer Breast cancer is a collection of diseases, organized into subtypes designating which treatments may be best for the patient and how aggressive the cancer is likely to be. One thing that is universal across all subtypes, though, is what makes them worse: metastasis. When cancer metastasizes, it spreads across... Continue Reading →
Reading time: 5 minutes Aishwarya Subramanian The life cycle of cells is a key piece of our understanding of cancer; as cells grow, they divide and produce two new “daughter” cells. For the cells to divide, grow and survive, it requires energy which they gain by metabolising glucose. However, every healthy cell that divides has... Continue Reading →
Reading time: 3 minutes Alex S. Woodell The tale of the canary in the coal mine dates back to 1911, when British miners began carrying caged canaries with them underground as a means of detecting toxic gases. The idea of using canaries as an early indicator is credited to John Scott Haldane, a Scottish physiologist... Continue Reading →
Reading time: 4 minutes Sara Musetti As fancy as the many cancer therapies on the market may seem, the underlying goal for all cancer medicines is the same: kill cancer cells. Chemotherapies damage the DNA of rapidly dividing cells enough that the cells die, immunotherapies train the immune system to kill cancer cells, radiation causes... Continue Reading →
Reading time: 3 minutes Alejandra Canales Finding treatments for lung cancer is hard because, simply-put, cancerous cells are extremely stubborn, and patients with non-small cell lung cancer can often acquire resistance to a treatment regimen. Researchers have been exploring the feasibility of “liquid biopsies,” whereby a non-invasive blood sample could be used to obtain information... Continue Reading →
Reading time: 5 minutes Jessica Desamero DNA is a two-stranded molecule that carries all our genetic information in the form of a code made up of four bases arranged in specific sequences. DNA has its own section of the cell, the nucleus, which serves to protect and contain it. As the cell divides and the... Continue Reading →
Reading time: 5 minutes Tamara Vital How do you stop an accident from happening? You could try to prevent the conditions that contribute to accidents by establishing rules that encourage and reward caution and safe behavior. On the road, licensing laws, traffic lights, and speed limits set the rules of the road, and those who... Continue Reading →
Reading time: 5 minutes Keighley Reisenauer Google “EMT,” and you’re likely to see images of paramedics and ambulances. However, there is another EMT that plays a much different role in disease and illness. Epithelial to mesenchymal transition (EMT) is normally associated with processes such as wound healing and development. Cancer hijacks EMT to participate in... Continue Reading →
Reading Time: 4 minutes Daniel Zhong Imagine this scenario: You are 90 years old, with gray hair and wrinkled skin. You always carry around a walking cane everywhere you go because the slightest movements from sitting down on a chair to brushing your teeth in the morning cause you tremendous pain in your joints, muscles,... Continue Reading →
Reading time: 3 minutes Kaitlyn Felsheim The nervous system is integral for communication between the brain and the rest of the body. It is responsible for relaying messages to breathe, eat, feel, blink, and perform other vital tasks. Neurons play a huge role in tissue development and specification, and it turns out that cancer cells... Continue Reading →
Reading time: 2 minutes Rachel Cherney *This article does not take the place of professional medical advice. Consult with your doctor* One of the most limiting aspects of drug development is the time it takes to design, optimize, and implement new drugs, which in turn limits patient treatment and survival. Unfortunately, for patients suffering from... Continue Reading →
Reading time: 4 minutes Kedar Puvar Designing new anticancer compounds is often a deliberate process, where the mechanism of action involves the blocking of a certain target, like a receptor or other cellular protein. Researchers would then optimize potential leads until a potent and effective drug is ready for clinical trials. This pipeline is considered... Continue Reading →
Reading time: 3 minutes Aishwarya Subramanian Cancer immunotherapy has gained a lot of traction in the last few years, as several novel therapeutics have made their way into the clinic. Among these new therapeutics, bispecific antibodies are some of the most unique. Unlike traditional antibodies, which have two arms that bind to the same molecule,... Continue Reading →
Reading time: 5 minutes Jessica Desamero From the start, our mission here at OncoBites has been to share the complicated nature of cancer with our readers and to shed light on breakthroughs in understanding and treating the disease. One of our biggest messages has been that “cancer” is really a family of different but related... Continue Reading →
Reading time: 3 minutes Kedar Puvar At first glance, mushrooms, being immobile and nutritious, seem to be rather unassuming. Why, then, would you want to turn to mushrooms of all things as a source of new medicines? It turns out that they make up for their evolutionary weaknesses with a powerful toolbox of molecular defenses... Continue Reading →
Reading time: 4 minutes Ariana Cardillo If you’ve been to the Midwest, it’s hard to miss the endless fields dedicated to the agriculture industry. If you live there, you are accustomed to the growing cycles and crop rotations of the fields. You probably are even desensitized to the massive machinery used to maintain these crops.... Continue Reading →
Reading time: 4 minutes Sara Musetti Picture this: You walk into a strange room. Maybe you’re at a friend’s house, or the restroom in a new coffee shop, or a hotel room. It’s dark, and you can’t see, but no matter where you put your hand, you just can’t find the light switch. You know... Continue Reading →
Reading time: 4 minutes You may have heard of the infamous thalidomide, a morning sickness drug that was patented in the 1950s. Its potent anti-nausea effects made it ideal as a remedy for morning sickness in pregnant women and thalidomide was sold in over 40 countries, going as far as to be made available over... Continue Reading →
Reading time: 5 minutes Payal Yokota Chemotherapy (chemo) can be prescribed alone and in combination with other therapies such as surgery, radiation, and immunotherapies (ie. vaccines, checkpoint blockade, etc). Since its discovery, the chemo field has greatly advanced, both in its development and ability to treat cancers. While surgery and radiation act locally to remove... Continue Reading →
Reading time: 4 minutes Sara Musetti Cancer immunotherapy has been a very hot topic here at OncoBites (because it’s a hot topic right now among cancer researchers too), but let me be super clear ⎯ it is COMPLICATED. Your immune system is balanced extremely delicately to avoid sending you into shock each time you are... Continue Reading →
Reading time: 3 minutes Kedar Puvar Diseases are typically caused by defective or malicious proteins. Traditionally, treatments for these diseases use a strategy of inhibition - use a small molecule that can block the offending protein from carrying out its function and thereby, bring things back to normal. But what if we went one step... Continue Reading →
Reading time: 4 minutes Kedar Puvar Cancerous cells by definition are constantly growing and multiplying and therefore have devised ways to sustain that growth. If one wishes to create a brand new therapeutic against cancer, it’s necessary to identify molecular mechanisms that cancer cells use to grow, then attempt to shut down that mechanism with... Continue Reading →
