Promiscuous kinase inhibitors: When having more than one partner can be good

Reading time: 4 minutes Chris Wang Unlike the Merriam Webster definition of promiscuous, describing a kinase inhibitor as promiscuous actually refers to the number of kinases it inhibits. The more promiscuous an inhibitor is, the higher number of off-targets it has. Traditional drug development strategies avoid promiscuous compounds because off-target effects can lead to side... Continue Reading →

Welcome to the (DNA) Neighborhood

Reading time: 3 minutes Rachel Cherney Six feet. Two meters. This is the length of DNA we have in each one of our cells. That’s almost the height of Michael Jordan! But those six feet of DNA need to fit into a tiny space that is between 5-10 micrometers. To put it into perspective, that's... Continue Reading →

Why Cancer is Hard to Treat

Reading time: 4 minutes Daniel Zhong Before we believe headlines proclaiming “Cancer is cured”, it is crucial to understand that developing a therapy that universally cures all cancers is highly unrealistic as our knowledge surrounding mechanisms of cancer progression advances. While we do have non-curative treatments for some types of cancer such as chemotherapy and... Continue Reading →

The Micro Problem with Cancer

MaryAnn Bowyer Reading Time: 3 minutes When we think of cancer cells, we often imagine a mastermind cell that has somehow managed to evade all of our body’s natural defenses as well as even modern day science. However, years of scientific research and publications have shown that the “mastermind” behind this particular cell is, in... Continue Reading →

How liquid biopsies could help monitor cancer treatment

Reading time: 3 minutes Alejandra Canales Finding treatments for lung cancer is hard because, simply-put, cancerous cells are extremely stubborn, and patients with non-small cell lung cancer can often acquire resistance to a treatment regimen. Researchers have been exploring the feasibility of “liquid biopsies,” whereby a non-invasive blood sample could be used to obtain information... Continue Reading →

PROTACs: Building better therapies

Reading time: 5 minutes Tamara Vital How do you stop an accident from happening? You could try to prevent the conditions that contribute to accidents by establishing rules that encourage and reward caution and safe behavior. On the road, licensing laws, traffic lights, and speed limits set the rules of the road, and those who... Continue Reading →

Finding a Cure to Aging and Cancer?

Reading Time: 4 minutes Daniel Zhong Imagine this scenario: You are 90 years old, with gray hair and wrinkled skin. You always carry around a walking cane everywhere you go because the slightest movements from sitting down on a chair to brushing your teeth in the morning cause you tremendous pain in your joints, muscles,... Continue Reading →

Many Anticancer Targets Could Be A Mirage

Reading time: 4 minutes Kedar Puvar Designing new anticancer compounds is often a deliberate process, where the mechanism of action involves the blocking of a certain target, like a receptor or other cellular protein. Researchers would then optimize potential leads until a potent and effective drug is ready for clinical trials. This pipeline is considered... Continue Reading →

BiTE Molecules for Cancer Therapy

Reading time: 3 minutes Aishwarya Subramanian Cancer immunotherapy has gained a lot of traction in the last few years, as several novel therapeutics have made their way into the clinic. Among these new therapeutics, bispecific antibodies are some of the most unique. Unlike traditional antibodies, which have two arms that bind to the same molecule,... Continue Reading →

The Rehabilitation of Thalidomide

Reading time: 4 minutes You may have heard of the infamous thalidomide, a morning sickness drug that was patented in the 1950s. Its potent anti-nausea effects made it ideal as a remedy for morning sickness in pregnant women and thalidomide was sold in over 40 countries, going as far as to be made available over... Continue Reading →

Evolution of chemotherapy: A look back in time

Reading time: 5 minutes Payal Yokota Chemotherapy (chemo) can be prescribed alone and in combination with other therapies such as surgery, radiation, and immunotherapies (ie. vaccines, checkpoint blockade, etc).  Since its discovery, the chemo field has greatly advanced, both in its development and ability to treat cancers. While surgery and radiation act locally to remove... Continue Reading →

Going on the offense: PROTACs as cancer therapy

Reading time: 3 minutes Kedar Puvar Diseases are typically caused by defective or malicious proteins. Traditionally, treatments for these diseases use a strategy of inhibition - use a small molecule that can block the offending protein from carrying out its function and thereby, bring things back to normal. But what if we went one step... Continue Reading →

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