The Rehabilitation of Thalidomide

Reading time: 4 minutes You may have heard of the infamous thalidomide, a morning sickness drug that was patented in the 1950s. Its potent anti-nausea effects made it ideal as a remedy for morning sickness in pregnant women and thalidomide was sold in over 40 countries, going as far as to be made available over... Continue Reading →

Evolution of chemotherapy: A look back in time

Reading time: 5 minutes Payal Yokota Chemotherapy (chemo) can be prescribed alone and in combination with other therapies such as surgery, radiation, and immunotherapies (ie. vaccines, checkpoint blockade, etc).  Since its discovery, the chemo field has greatly advanced, both in its development and ability to treat cancers. While surgery and radiation act locally to remove... Continue Reading →

Going on the offense: PROTACs as cancer therapy

Reading time: 3 minutes Kedar Puvar Diseases are typically caused by defective or malicious proteins. Traditionally, treatments for these diseases use a strategy of inhibition - use a small molecule that can block the offending protein from carrying out its function and thereby, bring things back to normal. But what if we went one step... Continue Reading →

The Many Faces of Tumor Scavenging

Reading time: 8 minutes Alex S. Woodell Prologue   The tumor microenvironment (TME) is a desolate place. Nutrients are sparse, and living conditions are hostile for the resident cells. This poorly perfused, alien landscape is filled with leaky, tortuous vessels. The interstitial fluid pressure is high, severely compromising nutrient delivery mechanisms. It’s not a place... Continue Reading →

Bacteria in Cancer therapy: Friend or Foe?

Reading time: 5 minutes Varshit Dusad Bacteria are our unallied neighbors, which depending upon circumstances chooses to be our friend or foe. While bacteria such as E.coli have often been the workhorses for molecular biology studies, they have other uses as well. Surprisingly, they have enormous potential for cancer therapy. No, I am not talking... Continue Reading →

Players in Cancer Metastasis and Relapse

Reading time: 5 minutes Rachel Cherney Patients with metastatic cancer usually have a lower survival rate than patients without metastatic cancer, so it is important to understand how metastatis occurs, so we can learn how to improve patient survivability. Metastatic cancer makes up about 90% of cancer deaths. Cancer metastasis occurs when tumor cells break... Continue Reading →

The Sweet Method of Cancer Detection

Kaye Alcedo Time is of the essence when it comes to the battle with cancer. Detecting tumors at an early stage increases the chance of patient survival to more than 80%. However, despite today’s advancing technology, about 48% of patients get diagnosed at a very late stage. This is because screening methods of many, if... Continue Reading →

A CAR-T therapy without the T-cells

Varshit Dusad Imagine a dystopian world. Here, some citizens of an otherwise well-functioning state have gone rogue and are running an anti-national agenda. They are always plundering the natural resources meant to be evenly distributed among the population. They are quite cunning as they start slowly by deviating from the laws of their natural order... Continue Reading →

Putting tumor cells to sleep

Yitong Li How to treat cancers has always been one of the biggest challenges in modern medical practice. While current chemotherapies and radiotherapies have shown significant progress, not all patients survive treatment, and only a portion of those who survive do so without suffering from significant trauma. Hence, early diagnosis and safer treatments are the... Continue Reading →

The Reproducibility Project

Alex S. Woodell As members of the biomedical research community, we are all familiar with the basic structure of the scientific method. We make an observation that identifies a problem, form a hypothesis based on known information, perform experiments to test this hypothesis, then draw conclusions that drive future research. However, there is a fifth... Continue Reading →

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