Reading time: 5 minutes Emily Chan During a holiday weekend, I had the chance to see one of the most beloved animals at my local zoo: the koala. Contrary to their adorable exterior, koalas boast strong arms and legs that hook around tree branches, allowing them to scale large eucalyptus trees. Recently, researchers at Institut... Continue Reading →
Tumor Microenvironment: A Determinant of Dormancy and Metastatic Growth
Reading time: 3 minutes Ifeoluwa Oyelade One of the most impactful breakthroughs in cancer research would be to completely eradicate all cancer cells in the body upon treatment, thereby preventing possible cases of cancer relapse. However, the ability of tumor cells to move out of their primary sites to reside in different organs in the... Continue Reading →
These Living Magnets Break Down Cancer’s Defenses
Reading time: 5 minutes Michael Marand From a young age, we are taught to protect ourselves from germs. From scrubbing our teeth to washing our hands, the hygienic routines we learned as kids help us steer clear of harmful single-celled organisms. And for good reason – research suggests bacterial infection is a significant risk factor... Continue Reading →
Can Only One Drug Cure All Types of Cancer?
Reading time: 3 minutes Leandro de Lima Coutinho While it would be miraculous to have a Panacea (or Elixir of Life) that would cure all diseases and prolong life, it took alchemists in the Harry Potter universe to create one. Taking a step away from fiction, it would still be incredible to have one drug... Continue Reading →
Knowing the Result Before the Test – ‘zAavatars’ Predicting Therapeutic Responses in Cancer Patients
Estimated reading time: 3 minutes Darshak Bhatt Wouldn’t it be nice if a cancer patient was given therapy only if it was going to work? Although it seems like a no-brainer, many patients undergo therapy without knowing how good the chances are for a successful outcome. Reasons for this uncertainty depend on the type and... Continue Reading →
Targeting Hypoxia in Cancer Therapies: Using the Lack of Oxygen as an Advantage
Reading time: 4 minutes Jessica Desamero With cancer, the environment that surrounds a tumor, or the tumor microenvironment (TME), can be just as important as the tumor itself in terms of cancer progression and drug resistance. How can this be? First, let’s take a look at what the TME is composed of. In a tumor... Continue Reading →
The Micro Problem with Cancer
MaryAnn Bowyer Reading Time: 3 minutes When we think of cancer cells, we often imagine a mastermind cell that has somehow managed to evade all of our body’s natural defenses as well as even modern day science. However, years of scientific research and publications have shown that the “mastermind” behind this particular cell is, in... Continue Reading →
How can we study cancer more accurately?
Reading time: 3 minutes Rachel Cherney If you have read other articles on Oncobites, you know that cancer is a collection of many diseases, and these diseases are complex. Cancer cells don’t live on their own; rather, they live among the normal tissue cells, immune cells, and bacteria in your body. Additionally, cancer cells can... Continue Reading →
Excess Adenosine: How Cancer Cells Use The Deaths of Their Neighbors to Protect Themselves
Reading time: 4 minutes Sara Musetti As fancy as the many cancer therapies on the market may seem, the underlying goal for all cancer medicines is the same: kill cancer cells. Chemotherapies damage the DNA of rapidly dividing cells enough that the cells die, immunotherapies train the immune system to kill cancer cells, radiation causes... Continue Reading →
The Double-Edged Sword of Collagen
Reading time: 4 minutes Sara Musetti If you’ve heard of collagen, it’s likely been in articles raving about its benefits. Maybe it was in the recent collagen broth craze, when everyone from Halle Berry to Dr. Oz claimed that the collagen in bone broth could prevent aging, improve your hair, cure arthritis, and so on.... Continue Reading →
Making New Connections: Possible Cross-Talk Between Tumors and the Brain
Reading time: 3 minutes Kaitlyn Felsheim The nervous system is integral for communication between the brain and the rest of the body. It is responsible for relaying messages to breathe, eat, feel, blink, and perform other vital tasks. Neurons play a huge role in tissue development and specification, and it turns out that cancer cells... Continue Reading →
Physical Education: The Anatomy of a Tumor
Reading time: 4 minutes Shaye Hagler Last spring, Sara introduced some of the ways tumors avoid being killed by both our own bodies’ defenses and the various treatments we throw at them; if you’ve kept up since then, you’ve read a lot about cancer biology and a tumor’s ability to send out signals to other cells... Continue Reading →
The Many Faces of Tumor Scavenging
Reading time: 8 minutes Alex S. Woodell Prologue The tumor microenvironment (TME) is a desolate place. Nutrients are sparse, and living conditions are hostile for the resident cells. This poorly perfused, alien landscape is filled with leaky, tortuous vessels. The interstitial fluid pressure is high, severely compromising nutrient delivery mechanisms. It’s not a place... Continue Reading →
Feeling the ‘heat’ from neighbors: Microenvironment driving cancers in the gut
Manisit Das Not long ago Tamara mentioned in her OncoBites article that it is often hard to determine what factors drive cancer. Even after a mutation responsible for fueling cancer growth is identified, we do not always know how that mutation contributes to tumor formation. Understanding these mechanisms is however quite important. As we gain... Continue Reading →
Bone found to abet Lung Cancer
Natasha Vinod Rudolph Virchow was one of the first physicians to study diseases from the standpoint of cells. He applied his cell theory “Omnis cellula e cellula” ("every cell originates from another cell") to the study of cancer and reasoned that cancer results from the failure of the regulatory mechanism of the cells to control... Continue Reading →
Immunotherapy in Pancreatic Cancer: Does Bacteria hold the answer?
Manisit Das Your gut is crawling with bacteria, despite your devoted hygiene practices. Disgusting for your sophisticated self, isn’t it? Surprising as it is, over the course of evolution our bodies tolerated the microbial communities in our body, even cherished them. Hundreds of thousands of bacteria and other microorganisms call us home and play a... Continue Reading →
What exactly is cancer?
Sara Musetti I came to a realization this week. Here at OncoBites, we made a cancer research blog and then… forgot to tell our readers what cancer is. And I know, most of you reading are thinking “I know what cancer is!” because you read about it all the time. And maybe, if you’re a... Continue Reading →
Engineering aggressive breast cancer subtype may allow more treatment choices
Manisit Das Breast cancer may sound like a single disease, but it is not. There are many subtypes of the disease, which guide the course of disease progression and treatment strategy. One of these subtypes, referred to as triple-negative breast cancer (TNBC) is particularly difficult to treat. Recently, researchers at Lund University, Sweden identified a... Continue Reading →