Reading time: 4 minutes Kedar Puvar Cancerous cells by definition are constantly growing and multiplying and therefore have devised ways to sustain that growth. If one wishes to create a brand new therapeutic against cancer, it’s necessary to identify molecular mechanisms that cancer cells use to grow, then attempt to shut down that mechanism with... Continue Reading →
Reading time: 3 minutes Manisit Das Previously at Oncobites, we discussed how small particles such as nanoparticles could be used for delivering drugs against cancer. The nanoparticles can carry the drugs to the tumor taking advantage of the leakiness of blood vessels running through the tumor. The leaky vessels allow the drug-carrying nanoparticles to enter... Continue Reading →
Reading time: 3 minutes Taylor A. Johnson February is Heart Month, wherein various organizations such as the American Heart Association and the National Institute of Health raise heart health awareness and promote practices that can lower heart disease or cardiovascular disease (CVD) development. CVD and cancer are unfortunately two of the primary causes of death... Continue Reading →
Reading time: 4 minutes Swetha Srinivasan Cancer therapies, like all other medicines, only make their way to patients after the completion of a lengthy process of extensive research studies involving animals and then people to make sure that the benefits of the drug outweigh the risks. These final research studies in people are commonly known... Continue Reading →
Reading time: 6 minutes Payal Yokota Despite the advent and access to a variety of targeted immunotherapy approaches, the current paradigm for solid tumors still remains if you can cut it out – you do! Depending on the grade of tumor and degree of metastasis, there’s a substantial risk of tumor resurgence. In those cases,... Continue Reading →
Taylor B. Poston Childhood acute leukemia is the most common pediatric cancer in the developed world. It accounts for one-third of all cases and affects 1 in 2000 children under the age of 15. More specifically, acute lymphoblastic leukemia (ALL) is the most common pediatric leukemia and case numbers have been increasing steadily at 1%... Continue Reading →
Reading time: 4 minutes Bekah Schulz Many people are excited about checkpoint inhibitors in cancer immunotherapy. In fact, the 2018 Nobel Prize in medicine was awarded for the development of two checkpoint inhibitors PD-1/L1 (Opdivo/Keytruda) and CTLA-4 (Yervoy). However, cancer immunotherapy is not a new concept. In fact, in 1986, recombinant interferon (IFN) alpha was... Continue Reading →
Reading time: 3 minutes Rachel Cherney At Oncobites, we write about current and cutting edge cancer research and how various lifestyles may affect cancer risk. However, we don’t often talk about the types of data that are generated from cancer research or how they can be used. Large informative data sets can be used to... Continue Reading →
Reading time: 5 minutes Alex S. Woodell Most of us have taken acetylsalicylic acid at some point in our lives. This popular drug was first brought to market in 1899 by Bayer who coined the brand name Aspirin. Aspirin belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) which are used to... Continue Reading →
Reading time: 4 minutes Varshit Dusad Studying the growth of the tumor is very important to devise an effective treatment against cancer. Often cancer tissues are buried deep inside the body and we need diagnostic methods that can tell us about their progression accurately without harming the body while not losing the accuracy. Therefore, invasive... Continue Reading →
Reading time: 4 minutes Morgan McSweeney A research team from UC Berkeley, UCSF, and UNC Chapel Hill has developed a new strategy to prevent unwanted side effects of toxic chemotherapy drugs. Often, choosing a dose of chemotherapy has to be balanced between how effective it will be at killing tumor cells and how toxic it... Continue Reading →
Reading time: 4 minutes Shaye Hagler Last spring, Sara introduced some of the ways tumors avoid being killed by both our own bodies’ defenses and the various treatments we throw at them; if you’ve kept up since then, you’ve read a lot about cancer biology and a tumor’s ability to send out signals to other cells... Continue Reading →
Reading time: 4 minutes Swetha Srinivasan “Congratulations, you are cancer free!” Hearing these words from the oncologist must come as an overwhelming relief to patients, as surviving a cancer diagnosis is one of the hardest things a person can do over their lifetime. Yet, beating cancer changes a person profoundly, and for many, the end... Continue Reading →
Reading time: 5 minutes Sara Musetti If someone were to ask you whether biological sex is related to the risk of cancer, you would might say yes--cis men can suffer from prostate and testicular cancer while cis women may suffer from cervical and ovarian cancer (and are at higher risk of breast cancer). Those all... Continue Reading →
Reading time: 5 minutes Manisit Das As humans, we are naturally programmed to recognize patterns. They help us detect cues in our surroundings and aid our decision making. We associate camouflage patterns with battle dress, assortments of red and green with the holidays; these recognition events help us to put things in boxes in our... Continue Reading →
So do we have a cure for cancer anytime soon? A question that every cancer researcher has probably faced multiple times in social situations. Cancer touches most of our lives, in one way or another. As cancer researchers, we consider it a privilege to be able to study the menacing disease that we are far... Continue Reading →
Reading time: 8 minutes Alex S. Woodell Prologue The tumor microenvironment (TME) is a desolate place. Nutrients are sparse, and living conditions are hostile for the resident cells. This poorly perfused, alien landscape is filled with leaky, tortuous vessels. The interstitial fluid pressure is high, severely compromising nutrient delivery mechanisms. It’s not a place... Continue Reading →
Reading time: 5 minutes Varshit Dusad Bacteria are our unallied neighbors, which depending upon circumstances chooses to be our friend or foe. While bacteria such as E.coli have often been the workhorses for molecular biology studies, they have other uses as well. Surprisingly, they have enormous potential for cancer therapy. No, I am not talking... Continue Reading →
Reading time: 5 minutes Yitong Li One of the biggest hurdles that stall new developments in cancer therapy is how to effectively deliver the treatment to the tumor. Most commonly, pharmaceutical agents and immunotherapies make their way to the tumor via the bloodstream. Hence, the successful emigration of these agents out of the blood vessels... Continue Reading →
Reading time: 3 minutes Nisitha Sengottuvel As cancer researchers and medical professionals, most of us at OncoBites have chosen to pursue a career fighting against cancer. Patients, however, have a fight that looks and feels a lot different than the fight we put forth every day in our labs. It is never easy and is... Continue Reading →
Reading time: 4 minutes Morgan McSweeney A recent study has found evidence that adolescents who are overweight or have obesity may be at a 407% increased risk of getting pancreatic cancer, the 6th most deadly form of cancer in the world. To determine this relationship, Levi et al. conducted a study of 1,087,358 Israeli Jewish... Continue Reading →
Reading time: 5 minutes Rachel Cherney Patients with metastatic cancer usually have a lower survival rate than patients without metastatic cancer, so it is important to understand how metastatis occurs, so we can learn how to improve patient survivability. Metastatic cancer makes up about 90% of cancer deaths. Cancer metastasis occurs when tumor cells break... Continue Reading →
Reading time: 5 minutes Shaye Hagler The discovery of accelerators and brakes in our immune system in the early 1990s was fundamental to designing the cancer immunotherapy platforms we use today, which is why it won the 2018 Nobel Prize in Medicine or Physiology. Now, immune checkpoint inhibitors like anti-PD-1 can work in tandem with... Continue Reading →
Reading time: 4 minutes Jason Tetro Imagine a world in which cancer is no longer a threat to the world. Naturally, the task sounds unachievable. But much like Ethan Hunt and his Impossible Missions Force team, the Australian government has accepted this mission in the hopes of eliminating cervical cancer from the country. Now, a... Continue Reading →
Reading time: 4 minutes Morgan McSweeney CRISPR-Cas9 is the molecular gene editing system that has inspired hopes for a solution to genetic disease. By studying how bacteria use the CRISPR-Cas system to defend themselves against bacteriophages (viruses that infect bacteria), scientists have developed methods to use those same molecular scissors to cut out human genes... Continue Reading →
Reading time: 6 minutes Manisit Das Sometimes double agents can be critical players in changing the course of conflicts, wars, and history. If you are a Potterhead like me, you are probably aware of how Professor Severus Snape played an important role in the wizarding world of Harry Potter. He instigated many of the major... Continue Reading →
Reading time: 4 mins Sara Musetti “I lit up like a Christmas tree, Hazel Grace.” This line, from John Green’s bestselling novel The Fault in Our Stars, hits hard. A young teenage survivor of cancer has had a widespread relapse picked up in one of his many routine scans since going into remission years earlier.... Continue Reading →
Taylor B. Poston Chlamydia is the most common sexually transmitted bacterial infection in the world, and 75% of infected women never develop symptoms. Furthermore, chlamydia will ascend from the cervix to the upper genital tract in 40% of infected women. This infection of the endometrium puts women at risk for pelvic inflammatory disease and infertility.... Continue Reading →
Tamara Vital We’ve talked at Oncobites about how many factors can cause or contribute to cancer. We’ve discussed how tumors arise from cells that have acquired mutations (could be inherited). Many of these factors have been related to external exposures like UV exposure from the sun or cigarette smoking that cause mutations that contribute to... Continue Reading →
Kaye Alcedo Time is of the essence when it comes to the battle with cancer. Detecting tumors at an early stage increases the chance of patient survival to more than 80%. However, despite today’s advancing technology, about 48% of patients get diagnosed at a very late stage. This is because screening methods of many, if... Continue Reading →
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