Profiling the killer: Using gene sequencing to guide management in pancreatic cancer

Manisit Das In earlier OncoBites articles, we discussed how genetic testing is increasingly used to guide cancer management. Cancer arises due to changes in our DNA sequences that make up our genes, which we refer to as gene mutations. By analyzing the genetic signatures within the tumor, clinicians can make better-informed choices to streamline the …

Feeling the ‘heat’ from neighbors: Microenvironment driving cancers in the gut

Manisit Das Not long ago Tamara mentioned in her OncoBites article that it is often hard to determine what factors drive cancer. Even after a mutation responsible for fueling cancer growth is identified, we do not always know how that mutation contributes to tumor formation. Understanding these mechanisms is however quite important. As we gain …

Stumbling before the beast: Not all cancer clinical trials end in drug approval

Manisit Das Since the beginning of OncoBites, we’ve talked a lot about immunotherapy: using our own immune cells to destroy the cancer cells? We can’t get enough of it! In one post, we highlighted a revolutionary approach recently approved by the US Food and Drug Administration (FDA) using genetically modified immune cells to fight cancer, …

Immunotherapy in Pancreatic Cancer: Does Bacteria hold the answer?

Manisit Das Your gut is crawling with bacteria, despite your devoted hygiene practices. Disgusting for your sophisticated self, isn’t it? Surprising as it is, over the course of evolution our bodies tolerated the microbial communities in our body, even cherished them. Hundreds of thousands of bacteria and other microorganisms call us home and play a …

Engineering aggressive breast cancer subtype may allow more treatment choices

Manisit Das Breast cancer may sound like a single disease, but it is not. There are many subtypes of the disease, which guide the course of disease progression and treatment strategy. One of these subtypes, referred to as triple-negative breast cancer (TNBC) is particularly difficult to treat. Recently, researchers at Lund University, Sweden identified a …