Weight during adolescence is associated with pancreatic cancer risk later in life

Reading time: 4 minutes Morgan McSweeney A recent study has found evidence that adolescents who are overweight or have obesity may be at a 407% increased risk of getting pancreatic cancer, the 6th most deadly form of cancer in the world. To determine this relationship, Levi et al. conducted a study of 1,087,358 Israeli Jewish …

Are humans immune to CRISPR/Cas9 gene editing?

Reading time: 4 minutes Morgan McSweeney CRISPR-Cas9 is the molecular gene editing system that has inspired hopes for a solution to genetic disease. By studying how bacteria use the CRISPR-Cas system to defend themselves against bacteriophages (viruses that infect bacteria), scientists have developed methods to use those same molecular scissors to cut out human genes …

The Reproducibility Crisis

Morgan McSweeney As Alex Woodell recently described, the preclinical research community is in a quiet crisis. Somewhere between 50% and 90% of results from early-stage academic cancer research are unable to be reproduced by industry scientists. Studies by several large multinational pharmaceutical companies and a number of other independent research groups have confirmed what they …

Immune cells work together to enable successful cancer therapy

Morgan McSweeney A group of researchers from the University of California - San Francisco recently found that the presence of a certain group of immune cells in tumors (“stimulatory dendritic cells,” or SDCs) can predict better cancer outcomes, at least in melanoma patients. For example, in patients treated with checkpoint inhibitors (drugs that work by …