Are humans immune to CRISPR/Cas9 gene editing?

Reading time: 4 minutes Morgan McSweeney CRISPR-Cas9 is the molecular gene editing system that has inspired hopes for a solution to genetic disease. By studying how bacteria use the CRISPR-Cas system to defend themselves against bacteriophages (viruses that infect bacteria), scientists have developed methods to use those same molecular scissors to cut out human genes... Continue Reading →

The Reproducibility Crisis

Morgan McSweeney As Alex Woodell recently described, the preclinical research community is in a quiet crisis. Somewhere between 50% and 90% of results from early-stage academic cancer research are unable to be reproduced by industry scientists. Studies by several large multinational pharmaceutical companies and a number of other independent research groups have confirmed what they... Continue Reading →

The Immune Landscape of Cancer

Morgan McSweeney  Cancer is not a single disease. It is a broad term that describes a number of related conditions in which cells’ growth has begun to bypass the usual checks and balances. To study the spectrum of cancers, the National Institutes of Health have established The Cancer Genome Atlas (TCGA), a collaborative project aimed... Continue Reading →

Cancer – how much of it is preventable?

Morgan McSweeney What percent of cancer cases are due to lifestyle choices or environmental conditions, and are therefore potentially preventable? Take a guess: 10%, 25%, 75%, or 90%? A paper by Anand et. al set out to answer exactly this question nearly ten years ago, pulling data from large-scale epidemiological studies across a large range... Continue Reading →

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