Category: Felicites Rapon

DUBTACs: A new therapeutic approach targeting proteins for cancer treatment

Reading time: 4 minutes Rapon Félicités While the degradation of disease-causing proteins [1] is now possible thanks to targeted protein degradation (TPD) technologies such as PROTACs [2], new targeted protein stabilization (TPS) technologies called DUBTACs [3] have been designed to stabilize and restore proteins that may promote cell proliferation when aberrantly degraded.  Tumor suppressing proteins... Continue Reading →

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Spatiotemporal Degradation of a Specific Protein as a New Cancer Therapy

Reading time: 12 minutes Felicites Rapon Recently, chemically engineered molecules have been produced to incite the degradation of a given protein. These molecules are called PROTACs [1], which stands for PROteolysis-TArgeting Chimeras.  How does the degradation of a protein work? The degradation of a protein, also called proteolysis, is achieved by the mechanism of ubiquitination.... Continue Reading →

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