Reading time: 5 minutes Anna Salamero Boix The tumor microenvironment has emerged as a potential therapeutic target in cancer therapy. Within the tumor microenvironment, tumor-associated immune cells regulate tumor progression and immune evasion (1). While most research has focused on targeting immune cell activity, fewer studies have interrogated the origin of tumor-associated immune cells. Expanding... Continue Reading →
Vorasidenib: A case study in bench-to-bedside translational research
Reading time: 6 minutes Spencer Maingi Identifying IDH mutations and their function In 2008, researchers studying brain tumors discovered something surprising. Patients with “secondary glioblastoma”, a uniformly lethal cancer that arises from a prior, less aggressive brain tumor (“low-grade glioma”), frequently had mutations in their tumor in the gene isocitrate dehydrogenase 1 (IDH1).1 Even more... Continue Reading →
