Reading time: 12 minutes Felicites Rapon Recently, chemically engineered molecules have been produced to incite the degradation of a given protein. These molecules are called PROTACs [1], which stands for PROteolysis-TArgeting Chimeras. How does the degradation of a protein work? The degradation of a protein, also called proteolysis, is achieved by the mechanism of ubiquitination.... Continue Reading →
Reading time: 5 minutes Susan Egbert Genomics has significantly advanced the field of oncology by elucidating the genetic components of a range of cancer types. This progress has contributed to enhanced cancer diagnoses and more efficacious treatments.1-3 From targeted therapies to immunotherapy, genomics has revolutionized the landscape of cancer care. However, the current status and... Continue Reading →
Reading time: 4 minutes Aya Elmeligy Tumor heterogeneity and lung cancer progression Intratumor heterogeneity is a key concept in the evolution and progression of many tumors, including lung cancers. As a tumor grows, its DNA continually develops mutations to overcome the effects of therapies. The cells that acquire these mutations are known as a subclone.... Continue Reading →
Reading time: 5 minutes Hema Saranya Ilamathi Viruses have long been associated with illnesses in humans, like the flu and AIDS, but many people are unaware that some viruses can be used to treat cancer. Oncolytic viruses (OVs) are natural or genetically engineered viruses that selectively target and destroy cancer cells. Using viruses to treat... Continue Reading →
Reading time: 5 minutes Charlotte Boyd Extracellular vesicles (EVs) are small bubbles which are released from the cell. Cells produce multiple types of EVs which are different sizes ranging from approximately 30 nanometres to 10,000 nanometres. A nanometre is 10 million times smaller than a centimeter. This means that EVs are tiny and not visible... Continue Reading →
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